Threshold today announced that a global agreement was signed with Merck KGaA, Darmstadt, Germany, to co-develop and commercialize TH-302, Threshold’s small molecule hypoxia-targeted drug. TH-302 is currently being investigated in a global Phase 3 clinical trial in patients with soft tissue sarcoma, a randomized Phase 2 trial in patients with advanced pancreatic cancer from which top-line results are expected in February, as well as additional clinical studies in other solid tumors and hematological malignancies.

Under the terms of the agreement, Merck will receive co-development rights, exclusive global commercialization rights and will provide Threshold an option to co-commercialize the therapeutic in the United States. In exchange, Threshold will receive an upfront payment of $25 million and could receive up to $35 million in additional development milestones during 2012. Threshold is also eligible to receive a $20 million milestone payment based on positive results from its randomized Phase 2 trial in pancreatic cancer. Total potential milestone payments are $525 million, comprised of $280 million in regulatory and development milestones and $245 million in sales-based milestones.

In the United States, Threshold will have primary responsibility for development of TH-302 in the soft tissue sarcoma indication. Threshold and Merck KGaA will jointly develop TH-302 in all other cancer indications being pursued. Merck KGaA will pay 70% of worldwide development costs for TH-302.

Subject to FDA approval in the United States, Merck KGaA will initially be responsible for commercialization of TH-302 with Threshold receiving a tiered, double-digit royalty on sales. Under the royalty-bearing portion of the agreement, Threshold retains the option to co-promote TH-302 in the United States. Additionally, Threshold retains the option to co-commercialize TH-302 allowing the company to participate in up to 50% of the profits in the United States based on certain revenue tiers. Outside of the United States, Merck KGaA will be solely responsible for the commercialization of TH-302 with Threshold receiving a tiered, double-digit royalty on sales in these territories.

“The addition of TH-302 to our pipeline provides an important opportunity in several different tumor types to expand our oncology development program,” said Susan Jane Herbert, Head of Global Business Development and Strategy, Merck Serono. “Given the fact that pancreatic cancer is a very difficult to treat indication, successful Phase II results could represent an important upside for our company.”

“We are excited by the new resources that our partnership is going to bring to the development of TH-302 and the expertise in clinical development and commercialization that Merck will contribute to this program,” said Barry Selick, President and CEO of Threshold. “This collaboration provides Threshold a strong and committed partner with a shared vision for TH-302.”

RTG Ventures Inc. (PINK: RTGV) rose 80.00% to $0.0018, on above-average volume of 77.85 million shares, a day after it released a brief update of its current technology development. Based in Washington, D.C., RTG Ventures offers music and entertainment technology solutions and digital marketing services.

Platinum Studios Inc. (OTC: PDOS) rose 30.00% to $0.0013, on above-average volume of 36.59 million shares. The entertainment company on Tuesday announced it is now developing sold out comic book series “The Weapon,” to bring to the big screen

Sunvalley Solar Inc. (PINK: SSOL) slid 2.78% to $0.0035, on volume of 13.97 million shares. Sunvalley Solar is a full-service solar power solution provider, offering system designs that are tailored to each of its client’s specific needs

Viper Networks Inc. (PINK: VPER) lost 49.23% to $0.0033, with volume of 155.54 million shares traded. Viper Networks is a provider of voice over Internet protocol (VoIP) products and services worldwide.

Viral Genetics Inc. (PINK: VRAL) slipped 6.67% to $0.0140, with volume of 12.54 million shares traded. San Marino, California-based Viral Genetics earlier today updated shareholders on its progress over the past year and provided its outlook for 2012.

Garb-Oil & Power Corp. (PINK: GARB) dropped 16.67% to $0.0005, on above-average volume of 76.35 million shares. Garb Oil & Power, together with its subsidiaries, engages in the manufacture and sale of equipment and products to the waste processing, energy, and recycling industries in the United States. The company last month commenced construction planning on its first project in Indiana.

“Having a large and increasing level of government debt relative to national income runs the risk of serious economic consequences,” Bernanke told the House Budget Committee. “Over the longer term, the current trajectory of federal debt threatens to crowd out private capital formation and thus reduce productivity growth.”

Bernanke recently announced that the Fed intends to retain interest rates near zero until the end of 2014! Gold and silver moved even higher in early trading as gold surged above $1760 and silver traded near the $34.4 threshold. All despite the fact that the RSI is showing overbought or near overbought on all gold and silver ETF’s such as: SPDR Gold Trust (NYSE:GLD), ProShares Ultra Silver (NYSE:AGQ), PowerShares DB Gold Double Long (NYSE:DGP), PowerShares DB Silver Fund (NYSE:DBS), and iShares Silver Trust (NYSE:SLV).

“While conditions have certainly improved over this period, the pace of the recovery has been frustratingly slow, particularly from the perspective of the millions of workers who remain unemployed or underemployed,” Ben said. “Moreover, the sluggish expansion has left the economy vulnerable to shocks.”

Next 1 Interactive Inc. (OTC: NXOI) gained 16.67% to $0.0021, on volume of 17.34 million shares. Next One Interactive is a multi faceted media company specializing in travel and real estate. The company plans the delivery of targeted content via multiple digital platforms including cable and video on demand TV broadcast, broadband and mobile. The company last month announced a deal to purchase The Giddy Gander Company and The Wumblers preschool television series and brand.

Louisiana Food Co. (OTC: LUSI) spiked 76.47% to $0.0090, with volume of over 674 K shares traded. In addition to pursuing its license for operating a legal online poker website,Louisiana Food focuses on locating, developing and commercializing food-related business opportunities in Louisiana.

Minerco Resources Inc. (PINK: MINE) drooped 50.00% to $0.0001, on high volume of 38.79 million shares. Minerco Resources is a development stage company engaged in the development, production, and provision of clean, renewable energy solutions in central America.

Sono Resources Inc. (OTC: SRCI) plummeted 58.16% to $0.205 on volume of over 211 K shares. It has a 52-week range of $0.15 – $1.29. Sono Resources is a mineral exploration company seeking to acquire, explore and develop highly prospective metal projects in Africa. The company in December released its first phase high resolution airborne magnetics interpretation in preparation for its Botswana drilling program this year.

Cannabis Science Inc. (OTC: CBIS) lost 4.05% to $0.0450, with volume of 29.04 million shares traded. Cannabis Science is a pioneering U.S. biotech company developing pharmaceutical cannabis (marijuana) products. The Denver, Colorado-based company today said news of recent FDA cancer drug approval puts the company in a very good position moving forward with its current cancer solutions.

Platinum Studios Inc. (OTC: PDOS) dropped 28.57% to $0.0010, on volume of 25.03 million shares. Platinum Studios is an entertainment company that controls an international library of thousands of comic book characters which it adapts, produces and licenses for all forms of media. The company yesterday confirmed it is now developing sold out comic book series “The Weapon,” to bring to the big screen.

Corinthian Colleges, Inc. (NASDAQ:COCO) has traded as high as $4.37 during today’s trading session and last traded at $3.96 for a gain of 30.69% from yesterday’s close. COCO shares have traded as high as $5.75 over the past 52 weeks, which is 31.13% off that high at last traded stock price. Get my next ALERT 100% FREE

COCO reported financial results today for the second quarter ended December 31, 2011. The results for the quarter exceeded previous guidance ranges for earnings per share and were within previous guidance ranges for revenue and new student enrollment.

“In the second quarter we remained focused on student outcomes, balancing expenses with current and projected enrollment, and improving the efficiency of back-end operations,” said Jack Massimino, Corinthian Chairman and Chief Executive Officer. “Our student attrition and graduate employment trends continue to make incremental improvement, primarily the result of reducing the risk profile of our students and our ongoing efforts to help students succeed.”

Sangamo Biosciences, Inc. (NASDAQ:SGMO) has traded as high as $4.50 during today’s trading session and last traded at $4.33 for a gain of 25.51% from yesterday’s close. SGMO shares have traded as high as $9.15 over the past 52 weeks, which is 52.67% off that high at last traded stock price.

SGMO, a leader in genome-editing technology, announced today that they have entered into a collaboration and license agreement to develop therapeutics for hemophilia and other monogenic diseases based on Sangamo’s zinc finger DNA-binding protein (ZFP) technology.

Multimedia Games Holding Company Inc (NASDAQ:MGAM) has traded as high as $9.57 during today’s trading session and last traded at $9.41 for a gain of 24.97% from yesterday’s close. MGAM shares have traded as high as $8.38 over the past 52 weeks, which is 8.39% over that high at last traded stock price.

MGAM today reported operating results for its fiscal 2012 first quarter ended December 31, 2011. Chief Executive Officer of Multimedia Games said, “With growing acceptance of our products in a variety of domestic gaming jurisdictions, Multimedia Games’ total revenues for the fiscal 2012 first quarter increased 21.6%. We more than doubled the number of units sold compared with the first quarter last year and recorded double digit year-over-year revenue growth in our gaming operations segment, as our quarter-end domestic installed base increased by 961 units, or approximately 11%, from the prior-year period.

Key Tronic Corporation (NASDAQ:KTCC) has traded as high as $8.18 during today’s trading session and last traded at $7.94 for a gain of 27.30% from yesterday’s close. KTCC shares have traded as high as $6.32 over the past 52 weeks, which is over 25.63% off that high at last traded stock price.

KTCC, a provider of electronic manufacturing services (EMS), yesterday announced its results for the quarter ended December 31, 2011. For the second quarter of fiscal 2012, Key Tronic reported total revenue of $84.5 million, up 38% from $61.0 million in the same period of fiscal 2011. For the first six months of fiscal 2012, total revenue was $154.2 million, up 24% from $124.4 million in the same period of fiscal 2011.

RadiSys Corporation (NASDAQ:RSYS) has traded as high as $7.71 during today’s trading session and last traded at $7.55 for a gain of 25.21% from yesterday’s close. RSYS shares have traded as high as $9.38 over the past 52 weeks, which is 19.5% off that high at last traded stock price.

RSYS is a leading provider of embedded wireless infrastructure solutions for telecom, aerospace, defense and public safety applications. Radisys’ market-leading ATCA, IP Media Server and Com Express platforms coupled with world-renowned Trillium software, services and market expertise enable customers to bring high-value products and services to market faster with lower investment and risk. Radisys solutions are used in a wide variety of 3G & 4G / LTE mobile network applications including: Radio Access Networks (RAN) solutions from femtocells to picocells and macrocells, wireless core network applications, Deep Packet Inspection (DPI) and policy management; conferencing and media services including voice, video and data, as well as customized mobile network applications that support the aerospace, defense and public safety markets.

Tirex Corp. (PINK: TXMC) rose 29.92% to $0.0033, with volume of 9.90 million shares traded. Tirex owns a patented tire recycling technology, the TCS System. The company earlier in January announced a joint venture deal with Wyoming Corporate Headquarters LLC to recycle scrap tires.

Treaty Energy Corp. (PINK: TECO) advanced 18.18% to $0.0978, with volume of 13.37 million shares traded. In a follow up to announcing its first successful oil well strike in Belize, the energy company today announced plans to add two new oil fields to its drilling program in the Central American country.

Solos Endoscopy Inc. (PINK: SNDY) spiked 40.00% to $0.0014 on above-average volume of 25.14 million shares. Solos Endoscopy, a healthcare instrument company, looks to to develop and market high quality and innovative instruments for the screening, diagnosis, treatment and management of medical conditions.

Thwapr Inc. (OTC: THWI) dropped 56.50% to $0.0174, on above-average volume of 15.85 million shares. Thwapr empowers brands to mobilize, monetize and socialize content, extending distribution reach while delivering the highest possible quality and user experience regardless of device, network or carrier.

EGPI Firecreek Inc. (OTC: EFIR) lost 25.00% to $0.0006, with volume of 14.35 million shares traded. EGPI Firecreek’s business and acquisition strategy is focused on producing oil and gas.

Alto Group Holdings Inc. (OTC: ALTO) slipped 16.67% to $0.0005 on volume of 17.07 million shares. Alto Group Holdings, an exploration stage company, engages in the acquisition and exploration of mineral resources in Mexico and Africa.

Unisys Corp. (NYSE: UIS) traded higher ahead of its fourth quarter and full-year financial report. The information technology company late today reported its third straight year of profitability and positive free cash flow. The stock gained 3.35% to $20.97, on volume of 1.33 million shares.

Jones Lang LaSalle Inc. (NYSE: JLL) gained 5.34% to $78.76, following the property management company’s better-than-expected fourth quarter results. Over 1.38 million shares traded hands today.

Vertex Pharmaceuticals Inc. (NASDAQ: VRTX) shares shot up 6.36% to $36.95 today as investors cheered the FDA’s approval of the company’s drug to treat an underlying cause of cystic fibrosis. Over 11.61 million shares traded hands today.

Fortinet Inc. (NASDAQ: FTNT) traded up 1.42% to close at $22.81, ahead of its earnings report. The specialty security software provider reported increases in its fourth quarter financial results, topping analysts’ expectations.

Polypore International Inc. (NYSE: PPO) shares hit a new 52-week low of $36.60, finishing the session down 29.92% to $38.08 on 26.37 million shares. The filter maker saw its shares downgraded by DA Davidson today.

RadioShack Corp. (NYSE: RSH) lost 29.81% to $7.18, a day after the electronics and accessories retailer warned of its fourth-quarter earnings shortfall. Shares slipped to a new 52-week low of $7.15 earlier in the session.

Pinnacle Airlines sees December 2011 traffic drop year-on-year – statistics have shown a decisive decrease in results. Available seat miles fell by 6.7% and revenue passenger miles dropped by 6.9% in December 2011 compared to the same month in the previous year. Passenger load factor for the final month of 2011 decreased by 0.1 percentage points to 72.5% compared to 72.6% in the corresponding month of 2010.

The company has been making progressive strides in order to avoid bankruptcy according to CEO Sean Menke. The company has been combining its jet fleets within subsidiary Pinnacle Airlines Inc. “This is a significant accomplishment but it required 18 months of hard work – substantially longer than originally anticipated,” Menke wrote. “As a result, it took longer than expected to achieve the potential integration efficiencies. In fact, we’ve had to maintain and hire additional employees and consultants to support the process. While the added expense has been a financial burden on our organization, we are already taking definite steps to begin achieving these synergies within the officer team, and more changes will take place throughout the organization in our first quarter of 2012.”

AMR Corporation (PINK:AAMRQ) has traded as high as $.73 during today’s trading session and last traded at $.70 for a loss of .84% from yesterday’s close. AAMRQ shares have traded as high as $1.20 over the past couple months under the AMR symbol, which is 41.66% off that high at last traded stock price.

AMR was delisted prior to the open of trading on January 5, 2012 and has since been trading on the pinksheets under the stock ticker “AAMRQ.”

The federal pension-insurance agency is increasing pressure on American Airlines to save its retirement plans instead of dumping its pension obligations. The Pension Benefit Guaranty Corp. said Tuesday it filed liens totaling $91 million against some assets of the airline’s parent company, AMR Corp., which filed for bankruptcy protection in November. AMR paid only $6.5 million of the scheduled $100M payment for its pension plans.

AMR and its lawyers have raised the possibility that the company might freeze or terminate retirement plans that cover about 130,000 employees and retirees. The company could make its intentions clear on Wednesday, when it presents new contract proposals to its unions.

American International Ventures Inc. (OTC: AIVN) hit a new 52-week high of $0.15 before closing the session at $0.135, up 237.50% from the prior day’s closing. American International Ventures is currently seeking other business opportunities to review and analyze for purposes of effecting a business acquisition or combination.

Xun Energy Inc. (OTC: XNRG) rocketed 330.00% to $0.0215, with volume of over 363 K shares traded. Xun Energy focuses to effect a merger, exchange of capital stock, asset acquisition or other similar business combination with an operating or development stage business.

Stellar Resources Ltd. (OTC: SRRL) spiked 158.93% to $0.0145, on above-average volume of over 232 K shares. Stellar Resources is in the business of oil and gas exploration and production, technological development, and the accumulation of oil and gas reserves..

Medical Alarm Concepts Holdings Inc. (PINK: MDHI) gained 17.3% to $0.0122, on high volume of 32.74 million shares. Medical Alarm Concepts develops and manufactures innovative products and practical solutions within the framework of a vast growing marketplace. The company recently launched a media campaign for the MediPendant, the company’s first fully-monitored medical alarm system that allows the user to speak and listen directly through the pendant.

Atrinsic Inc. (PINK: ATRN) advanced 24.6% to $0.0810, with strong volume of 32.21 million shares traded. Atrinsic operates as a direct to consumer Internet marketing company. The company sells entertainment and lifestyle subscription products direct to consumers through the Internet.

Viper Networks Inc. (PINK: VPER) rose 61.5% to $0.0021, on heavy volume of 283.59 million shares. The technology company earlier today announced that LEDs America has agreed to award the company with complete sales and marketing export rights with 100% exclusivity for LEDs America’s LED products for the entire India, as well as Saudi Arabia for the next 5 years.

FriendFinder Networks Inc (NASDAQ:FFN) has traded as high as $1.14 during today’s trading session and last traded at $1.04 for a gain of 16.85% from Friday’s close. FFN shares have traded as high as $10.01 over the last 52 weeks, which is nearly 90% of that high at last traded stock price. Get my next ALERT 100% FREE

FriendFinder Networks Inc. (www.FFN.com) is an internet-based social networking and technology company operating several of the most heavily visited websites in the world, including AdultFriendFinder.com, Amigos.com, AsiaFriendFinder.com, Cams.com, FriendFinder.com, BigChurch.com and SeniorFriendFinder.com, and social commerce company operating JigoCity websites in more than five countries, providing members high quality, daily deals that are relevant to their individual lifestyles. FriendFinder Networks Inc. also produces and distributes original pictorial and video content and engages in brand licensing.

Renren Inc (NYSE:RENN) has traded as high as $6.12 during today’s trading session and last traded at $5.87 for a gain of 11.81% from Friday’s close. RENN shares have traded as high as $24 over the last 52 weeks, which is 75.5% of that high at last traded stock price.

RenRen Inc. operates the leading real name social networking internet platform in China. It enables users to connect and communicate with each other, share information and user generated content, play online games, listen to music, shop for deals and enjoy a wide range of other features and services. RenRen’s platform includes the main social networking website Renren.com, the online games center game.Renren.com, the social commerce website nuomi.com, and the newly launched professional and business social networking service website jingwei.com. It had approximately 117 million activated users as of March 31, 2011.

Quepasa Corporation (AMEX:QPSA) has traded as high as $5.25 during today’s trading session and last traded at $4.87 for near even percentage change from Friday’s close. QPSA shares have traded as high as $15.45 over the last 52 weeks, which is nearly 68.5% of that high at last traded stock price.

Quepasa Corporation is the public market leader for social discovery and owner of Latin-American platform Quepasa and North-American platform myYearbook. The company makes meeting new people fun through social games and apps, monetized through both advertising and virtual currency. In addition to Quepasa and myYearbook, the Company operates Quepasa Games, a cross-platform social game development studio. Get my next ALERT 100% FREE

Quepasa has strong reach throughout the world, with a concentration across North and South America. Quepasa is headquartered in New Hope, Pennsylvania. For more information about the Company, go to www.quepasacorp.com, or join for free at www.Quepasa.com, myYearbook.com, or via the myYearbook app on iPhone, iPad, and Android.

Facebook, Inc. IPO is coming soon… expecting to file on Wednesday.